Based on the buffeting force model and the model for the wind-vehicle-bridge system presented in the paper, an approach to study the coupling vibration of wind-vehicle-bridge system considering the coherence of buffeting forces was developed and the corresponding calculating program was built. The application of the proposed methodology on the Jiangshun Bridge in China was presented as a numerical example. The coherence of the buffeting forces of the bridge and the aerodynamic parameters of the bridge and the vehicle considering the aerodynamic interference between the bridge and the vehicle were measured in wind tunnel. The effect of the coherence of buffeting forces of the bridge on the dynamic performance of both the bridge and the vehicles under cross winds were discussed. It is found that the coherence of the buffeting forces of the bridge has significant effect on the dynamic responses of the bridge, and some impact on the dynamic responses of the vehicle.