Taking a typical 500kV full combined substation framework as the background, the shape factor of the wind load and the dynamic response factor of this structure were investigated by combining wind tunnel tests and finite element calculation analysis. Three single beam models and a full combined framework model were produced at 1∶11 and 1∶32 model scale, respectively. Then a series of experiments were conducted to test the shape factors. Finally, based on the wind tunnel results, the wind-induced response analysis of the full combined substation framework was done, and the dynamic response factors were obtained. The results show that the test values of the shape factors of beams A, B, and C are 2.23, 2.35 and 2.18, which is 8%, 14% and 7% larger than the corresponding values stipulated in load code for the design of building structures and the technical code for the design of substation buildings and structures. For a 2% damping ratio, the dynamic response factors of the beams at 20m, 26m and 34m are 1.60, 1.80 and 1.58, respectively. And those are 7%, 6% and 5% larger than the dynamic response factors prescribed in the technical code for the design of substation buildings and structures. This indicates that the design loads specified in current domestic provisions for this structure are non-conservative.