Non-isothermal crystallization transformation kinetics and isothermal crystallization kinetics of prepared Zr57.5Cu27.3Al8.5Ni6.7 bulk metallic glass (BMG) were investigated with differential scanning calorimetry (DSC). In isochronal mode, the values of activation energy, Eg, Ex, Ep1 and Ep2, calculated by Kisinger method are 409.70 kJ/mol (± 60.07 kJ/mol), 335.53 kJ/mol (± 39.94 kJ/mol), 323.95 kJ/mol (± 15.21 kJ/mol) and 187.75 kJ/mol (± 13.27 kJ/mol), respectively. In isothermal mode, the S-shape relation curves of crystalline volume fraction and temperature reveal the typical transition of nucleation and growth. The Avrami exponent n ranges from 3.0 to 4, indicating the crystallization mechanism in the Zr57.5Cu27.3Al8.5Ni6.7 BMG is mainly interface-controlled. The crystal growth way changes from two-dimensional growth with decreased nucleation rate to three-dimensional growth in the isothermal crystallization process. In isothermal mode, the mean value of activation energy is 434.81 kJ/mol, which is higher than that in the isochronal mode.