According to the factors affecting the diameter size (i.e. mass flow rate, pipeline length and pressure drop), this article analyzed the pipeline design model of Rubin from the three aspects and established their corresponding numerical models. Furthermore, the reliabilities of the proposed numerical models were validated by another pipeline design model (i.e. the MIT model). Besides, the economic cost of CO2 pipeline transportation was also estimated through the cost analysis of the total pipeline capital investment and the additional pressure station cost. The research result shows that: (i) the proposed models share the same variable change rules and numerical model types with the validation model, and (ii) all of them have high correlation with numerical models (their correlation coefficients R2 are larger than 0.970). The pipeline design and cost analysis proposed in this work have some reference value for the process design of CO2 pipeline transportation.