In order to explore the failure process and fragments ejection rule of blast case for masonry walls, the AUTODYN program was used to simulate the dynamic response of masonry walls under close range blast load. The distribution of blast pressure on masonry walls and debris ejection laws were obtained. The results show that the destruction rules of 120 mm, 240 mm masonry walls, and the strengthened 240 mm wall under close range blast load are similar. The debris ejecting speed of 240 mm wall and the strengthened 240 mm wall declines obviously when compared with 120 mm masonry wall. The debris ejecting speed of the strengthened 240 mm wall declines significantly on account of the consolidated film of PU. Moreover, the relationship between ejecting speed and scaled distance is similar to the relationship between scaled distance and peak overpressure.