FE models of different oblique crash cases between passenger car and SUV in different crash overlaps and impact severities were developed to investigate the injury responses of the driver in oblique crashes. The method combining the FE and multi-body software was used to analyze the injury response of driver in different cases. It is shown that the impact severity and the crash overlap have great influence on the injury response of the head and the lower limb. It is also indicated that the driver injury response in 30% crash overlap case is more sensitive to the impact severity and the driver injury response in 70% crash overlap case is the lowest in three crash overlap cases.