To improve the accuracy of the fracture parameters of interface fracture structure, based on the interfacial fracture mechanics and smoothed finite element method, Cell-Based smoothed finite element method was proposed to solve the fracture parameters of bi-material interface crack, and the smoothing cells of the interaction integral method was given to obtain the stress intensity factor. The central interface cracks of bi-material infinite plate were simulated, and the FEM calculation results and the analytical solution were compared. The relationships among the number of elements, the number of subdomain and normalization stress intensity factors as well as the convergence of the proposed method were discussed. Numerical example results show that this method has good convergence and high accuracy and can be designed and manufactured as necessary references for researchers and engineers in multilayer materials.