The effects of rolling mode (conventional rolling and high strain-rate rolling in a single pass) on bio-corrosion behavior of magnesium alloys (ZK60, Mg-4Zn-0.3Ca, Mg-4Zn and pure Mg) were investigated by optical microscope (OM), scanning electron microscope (SEM), mass loss of immersion testing and tensile testing. The results showed that magnesium alloy prepared by high strain-rate rolling exhibited lower average corrosion rate and reduced slightly in ultimate tensile strength, compared with the counterpart prepared by conventional rolling. Meanwhile, better corrosion resistance was also exhibited, which could be attributed to the grain refinement, higher DRX extent, fewer twins, and relatively coarse remained second phases. The as-rolled alloys also exhibited a uniform filiform corrosion due to the lower fraction and finer size of the second phase.