This paper proposes a new multi-objective hybrid swarm optimization method for active control system based on particle swarm algorithm and differential evolution algorithm, in which the parameters of controller, and the number of and allocation of actuator are synchronously optimized. The basic idea is as follows: The different algorithms are used to complete the evolution of corresponding population, the non-dominated solution set is achieved based on the dealer principle, and the leader selection based on boundary point geometry center is adopted. Meanwhile, the simulated annealing algorithm is used for the secondary local search, the two indexes reflecting the structural vibration control effect and performance of control strategy are used as the optimization objective function. Finally, a ASCE 9-story benchmark model is used as a numerical example to validate the effectiveness of the proposed method. Compared with the conventional MODE, MOPSO, and MOHA algorithm, the MOHO-SA algorithm has better convergence curve and distribution of the pareto solution sets.