Microwave assisted ball milling was employed to reduce Cr (VI) in wastewater, and single factor method was used to observe the change of the iron ball quality, the amount of reduced iron powder and the effect of pH on the reduction of Cr (VI). These experimental results show that the greater the ball material ratio and the amount of reduced iron powder, the smaller the pH, the faster the reduction speed of Cr (VI). In the neutral solution, through microwave assisted ball milling, the concentration of Cr (VI) can be reduced from 50 mg/L to 0.473 mg/L in 55 minutes, and the production is detected as FeCr2O4 by XRD with XPS. When the pH is 2, the initial concentration of 300 mg/L Cr (VI) can be reduced to below 0.5 mg/L in 6 minutes. Therefore, the industrial wastewater containing Cr (VI) can be efficiently disposed by microwave assisted ball milling equipment.