The existing studies on the fatigue analysis for suspender of arch bridges have been found with limited consideration of the vehicle-bridge coupled vibration and road surface progressive deterioration，and those previous studies cannot reflect the actual fatigue property of the suspender.Based on the international general evaluation system of pavement roughness，a model of road surface progressive deterioration of each operation stage was established.A new model of fatigue analysis was then established by considering the effects of random traffic load model and road surface progressive deterioration.An arch bridge was taken as an example，and the differences of the fatigue performance analysis results for the typical suspender were analyzed and compared by the two situations with or without consideration of the conditions of the bridge deterioration and vehicle-bridge coupled vibration.Compared with the existing numerical method，the analysis results obtained by the proposed method show that the effects of vehicle-bridge couple vibration and road surface progressive deterioration on the suspender fatigue are significant，and the suspender fatigue value obtained by considering the above two factors can be improved by 15 years to 30 years.Therefore，the numerical results are significant for the maintenance of existing arch bridges.