To investigate the global and local dynamic response of plate-truss composite structure (i.e.,cable-stayed bridge induced by train-bridge coupling vibration),a numerical approach was presented based on train-bridge coupled dynamics. A coupled train-bridge system model composed of a 3D vehicle model with 31 degrees of freedom,a 3D fine bridge model established by the direct stiffness method,and an assumed wheel-rail spatial contact relationship based on the Hertz nonlinear contact model and nonlinear creep force model were developed. The self-developed software TRBF-DYNA was applied to analyze the dynamic responses,such as acceleration,displacements and stresses. The Dongting Lake three tower cable-stayed bridge with a main span of 406 m in Jingyue railway line was taken as an example. The global and local dynamic response of the bridge,variations of running safety,and ride comfort index were discussed under different routes,speeds and track irregularities conditions. The results show that the local dynamic response of orthotropic steel bridge deck is much larger than the response of steel truss girder. Dynamic coefficient of large-span cable-stayed bridge is small,and the influence of the speeds and track irregularity on dynamic coefficient of large-span cable-stayed bridge is insignificant. The lower chord and web members of steel truss girder are in high cycle fatigue stress state,which should be paid more attention in the study of their fatigue properties. Further,the dynamic response of bridge,running safety indexes and ride comfort index satisfy the code requirements under the designed running speed.