The three-dimensional finite element model of a 50-storey steel frame-concrete core wall structure was established. The along-wind induced vibration analysis of the structure with/without damping outrigger storeys under the simulating wind load was performed, and the influence of the number and location of the damping outrigger storey on wind resistance performance of the 50-storey steel frame-concrete core wall structure was discussed. The analysis results show that the rational number and optimal arrangement of the damping outrigger storey can effectively improve the comfort level and wind resistance performance of the tall steel frame-concrete core wall structure. If the maximum inter-storey displacement angle or the peak roof displacement is taken as control objectives, damping outrigger storeys should be installed near the central structure so as to obtain better vibration reduction effect. If the peak roof acceleration is taken as control objectives, damping outrigger storeys should be installed near the top of the structure so as to obtain better vibration reduction effect. Assuming that the total damping coefficients and other parameters of single viscous damper are unchanged, wind resistance performance of high-rise buildings with different damping layers are compared, and the results indicate that the total performance of the buildings with multiple damping layers is better．