Abstract:Ferulic acid and ferulamides are a class of natural products and derivatives with important biological activity and pharmacological effect. Ferulic acid (1) was synthesized from vanillin through Knoevenagel reaction. Then, a series of ferulamides (2-9) were synthesized through reaction of ferulic acid with amines using DCC as dehydrating agent and DMAP as the catalyst. Compounds 7 and 8 are new compounds. The structures of all synthetic compounds were characterized by NMR、MS and IR spectra. This synthetic method has the advantages of easy availability of starting materials, simple operation and high yield.