Fire resistance of Concrete-filled RPC tube (CFRT) columns were investigated by experimental study. Seven large-scale CFRT specimens were performed by heating test and axial compression test after elevated temperature. The test parameters included control temperature, volumetric stirrup ratio and stirrup arrangement mode. The test results showed the spalling of concrete was not observed during elevating temperatures. The compressive performance of CFRT column after high temperature decreased with the rising control temperature. Both increasing the volumetric stirrup ratio and arranging double layers of spiral hoops were effective measures for improving the mechanical properties of the CFRT columns after high temperature. Compared with the existing test results, the residual load carrying capacity ratio of the CFRT after elevated temperature was higher than that of the ordinary steel-confined column. The CFRT columns exhibited excellent fire resistance.