In the pedestrian-vehicle collision accident, pedestrian may suffer head injury not only from the primary impact with the vehicle but also from the secondary impact with the ground. In order to comprehensively analyze the influence of vehicle front-end structure parameters on pedestrian kinematics and head injury in primary and secondary impacts，in this paper, a series of multi-body models of pedestrian-vehicle collisions were constructed by utilizing the MADYMO code, with adjusting parameters of windshield angle（WA），bonnet angle（BA），bonnet length （BL），bonnet leading edge height（BLEH） and ground clearance（GC）. The influence significance of vehicle parameters on the pedestrian kinematics and injury was analyzed by using multiple linear regression analysis. The results indicate that BLEH is the most significant influence factor on head HIC value（car）（p<0.01) and pedestrian rotation angles in the primary and secondary impact，respectively.The influence of BA on the head angle acceleration （car） is more significant than that of BLEH. WA, BL and GC show a less influence on the kinematics and injuries of pedestrian. The lower BLEH provides better protection of the head in the primary collision, but it can easily lead to the head to collide with the ground firstly in the secondary impact, which increases the risk of head and neck injury. A quantitative analysis of the effect of vehicle front-end structure parameters on the primary and secondary impact was also conducted in the study, and the results can provide some reference for vehicle safety design.