The influences of a new cladding quenching process and subsequent aging treatment on the microstructure and mechanical properties of Al-Zn-Mg-Cu alloy plates were investigated based on residual stress measurement，in-situ electrical resistivity characterization，Vickers hardness testing and transmission electron microscope（TEM） observation. The results show that the cladding quenching process can effectively reduce the quenching residual stress and dislocation density of Al-Zn-Mg-Cu alloy. The in-situ electrical resistivity results show that，with the increased cladded thickness（0.2~0.6 mm），the aging precipitation behavior of cladded quenched samples is more similar to that of the uncladded quenched sample. The optimized artificial peak aging processes for the cladded quenched alloys were obtained on the basis of in-situ electrical resistivity and hardness testing results. Under such optimized artificial aging conditions，the cladded quenched samples can maintain the similar nano-precipitate characteristics and mechanical properties to that of uncladded quenched sample.