In order to improve the production scheduling ability of the cigarette，a high-efficiency cigarette production scheduling method based on the support of the MES system is put forward. The MES system support model is constructed，and the output value of the production schedule is calculated in the model. And taking the scheduling output value as an adaptive learning coefficient，establishing a quantitative evaluation parameter screening model of the cigarette production scheduling，screening the quantitative evaluation parameter of the cigarette production scheduling，and outputting the test statistic quantity of the cigarette production scheduling，and constructing an optimized dispatching function of the cigarette production so as to realize the optimization of the cigarette production scheduling. The simulation results show that the method is good in convergence and high in yield，and is suitable for cigarette production scheduling.