In order to study the influence of end plate thickness and node types on seismic behavior of prefabricated eccentrically braced steel frame，pseudo-static tests of two eccentrically braced semi-rigid steel frames with different end plate thickness and one eccentrically supported rigid steel frame were carried out. Based on the testing results, the main characteristics of the failure modes，load-deformation hysteresis curves, skeleton curves, lateral ductility coefficients and equivalent viscous damping coefficients of the specimens are analyzed and discussed. The results show that the prefabricated eccentrically braced steel frame with end plate connections has good seismic performance. The thickness of the end plate is an important factor affecting the energy dissipation capacity of the prefabricated eccentrically braced steel frame, and the energy dissipation capacity of the structure increases by 43.32% with the thickness of the end plate increasing from 16 mm to 24 mm. At the same time, affected by the slip of high-strength bolt-end plate connection, the hysteresis curve of semi-rigid steel frame with eccentric support is“bow”，showing a phenomenon of “pinching”.