In order to study the seismic response law of the subway station structure with integrated superstructure，based on the above ground underground integrated structure system of rail transit and single subway station structure system，the shaking table test of silty sand was carried out. The seismic response of subway station structure is studied from the acceleration and strain，and the results are compared with each other. The results show that: 1) with the increase of seismic intensity，the acceleration peak of soil and the structure increases gradually，while the acceleration amplification coefficient decreases gradually. The variation law of acceleration along the buried depth is related to the type of ground motion; 2) with the increase of seismic intensity，the amplitude of tensile strain of the integrated superstructure gradually increases. In the model，the amplitude of tensile strain at the end of the column is the largest，followed by the side wall，and the floor shows the smallest value. 3) The acceleration and strain of the integrated subway station structure are smaller than that of the single subway station structure，while the acceleration variation law is similar. With the increase of seismic intensity，the difference of strain amplitude gradually increases，while the difference increase show the gradual decrease and converge trend.