In the aircraft mobile assembly line，the skill level of human resources can be improved through a certain period of learning by doing. For this phenomenon，a multi-project portfolio scheduling problem considering the skill evolution of flexible resource under the known expected human resource structure is proposed，and a mixed integer programming model is established to minimize the number of projects and the total input cost required to achieve the target human resource structure. To solve this model，a hybrid multi-objective teaching optimization algorithm with multi-layer linked list structure encoding is designed，and the neighborhood search is combined to improve the local search ability of the algorithm. Finally，the results of experimental data verify the effectiveness of this model and algorithm.