In order to establish a post-disaster performance evaluation method for self-tapping screw joints under typhoon, firstly, the time-history wind pressure coefficient data of the roof based on wind tunnel tests were collected. Secondly, typhoon simulation was carried out to get information on wind speed and direction. Then, the coefficient matrix of roof wind pressure during typhoon transit was calculated by rain-flow analysis method. Finally, the node resistance degradation model under different wind speeds was calculated. Combined with the typhoon load model, the time-varying reliability index of self-tapping screw joints in coastal cities was obtained by the Monte Carlo simulation method. Thus, the wind resistance performance evaluation of self-tapping screw joints based on probability is realized. Besides, the analytical solutions of the wind speed and wind direction of the simulated typhoon are given according to the method of simulating typhoon. Simultaneously, the mathematical model of resistance degradation of self-tapping screw joints caused by the typhoon is obtained. Through the analysis of a numerical example, it is concluded that the reliability of self-tapping screw joints is significantly reduced when the typhoon induced resistance degradation is considered. When evaluating the reliability of self-tapping screw joints for light steel roofing, the target reliability indicators in China's codes are relatively conservative.