To achieve the ductility design of steel staggered truss framing systems and improve seismic behavior of the whole structure, this paper proposes a seismic design method for the steel staggered truss framing system by studying the design method of web members and the limit of the inter-story drift ratio. The typical failure mechanism of the steel staggered truss framing systems is analyzed firstly, and based on the expected failure mode of the chords failure in vierendeel panels, the internal force calculation model of truss members under horizontal earthquake and the adjustment method of internal force of web members under rare earthquake are proposed. Secondly, based on the expected failure mode and the ultimate deformability of truss, the composition of truss inter-story drift ratio under rare earthquake is analyzed, and the limit value of elastoplasticity inter-story drift ratio under different lengths of vi? erendeel panels are derived and proposed. Finally, the seismic design method and process of steel staggered truss framing systems under horizontal earthquake are proposed. The calculation analysis of examples shows that the seis? mic design method proposed in this paper can effectively dissipate the seismic energy and achieve the seismic design goals of“strong web member, weak chord member”and“no collapse in the strong earthquake”.