The phenomenon of secondary salinization caused by water and salt migration of subgrade soil has been observed to take place in Northwest China. To clarify the dynamic rebound characteristics of the coarse-grained sulfate saline soil (CGSSS) subgrade under the influence of load, humidity, and salinity, indoor dynamic triaxial tests were conducted to study the evolution law of dynamic resilient modulus of CGSSS under fifteen stress paths, three wa? ter contents and four salt contents. The test results show that the dynamic resilient modulus of CGSSS with the same humidity increases with the increase of confining pressure and bulk stress, but with the increase of the deviator stress, the dynamic resilient modulus shows a lower development trend. The salt content first increases and then de? creases, and the high salt content increases. At the same time, the higher salt content results in the more obvious the influence of deviator stress and bulk stress on the dynamic resilient modulus; under the same stress level, the dy? namic resilient modulus of CGSSS increases gradually with the increase of water content and salt content, and the ef? fect of salt tends to be more significant than that of water. Based on the stress dependence of dynamic resilient modu? lus revealed by the test, two widely applicable theoretical models are selected from typical three-parameter compos? ite models related to stress, and then the best prediction model is compared. The error analysis shows that the ob? tained Ni model has higher rationality and reliability, and a parameter prediction formula of the model with higher precision is established. Through the further comparative analysis of the predicted value and the experimental value, the accuracy of the parameter prediction formula of the model is verified, which is suitable for predicting the dynamic resilient modulus of CGSSS. The research results can provide dynamic parameters for the structural design of sub? grade and pavement in saline soil areas.