In order to study the effect of the application of air carrying energy radiant air-conditioning system （ACERS）in laboratory animal rooms on animal welfare and energy saving of air-conditioning system，Fluent soft? ware is used to numerically simulate the operating state of traditional air-conditioning system and ACERS. The distri? bution differences of wind speed，temperature and humidity and ammonia concentration under the same ventilation times，and the effects of different ventilation times of ACERS on indoor wind speed，temperature and humidity and ammonia concentration are compared and analyzed. It is found that the ACERS can keep the temperature gradient in the laboratory animal rooms below 0.46 ℃/m and the relative humidity between 40%~70%，and because the control of fresh air can improve the problem of high energy consumption in the laboratory animal rooms to a certain extent. This provides a reference for the welfare of laboratory animals and the energy saving of laboratory animal rooms.