In order to explore the impact of temperature step change on the thermal comfort of the human body under radiant air-conditioning mode and provide a certain reference for the control and adjustment of radiation airconditioning systems, this study explored the change law of total and local subjective thermal response, thermal comfort and skin temperature with time for 20 subjects under three different air conditioning modes (convection, radiant floor, and radiant ceiling), by creating a cool-neutral temperature step change in an artificial well-controlled climate chamber. The testing results of the above physiological parameters show that the skin temperature in the mutation to the radiant neutral environment exists a hysteresis, and human sympathetic nerves perform more actively in a dynamic radiant environment. Subjective questionnaire analysis shows that the subjects’comfort and thermal pleasure are better in the dynamic radiant heat environment, and subjective thermal sensations appear psychological advance ment, with more prominent advantages of the dynamic radiant floor; and the back, calves, and feet are the of the average skin temperature of the human body over time. A correlation model based on the Knothe function was established to quantify the response characteristics of human physiological adjustment under three conditions. Finally, according to the change law of the average skin temperature and its rate of change and the average thermal sensation, thermal sensation prediction models for three conditions are established, which simplify the solution of human thermal sensa?tion prediction in a dynamic environment.