The wind turbine is an atypical high-rise structure with a low damping ratio, and its seismic response spectrum is designed without considering the soil-structure interaction (SSI). Therefore, the seismic response spectrum of wind turbine design is proposed considering the SSI effect. 3 034 ground motions with different characteristics are selected and classified according to the building seismic code. Based on the S-R model, a single degree of freedom analysis model of wind power structure considering the SSI effect is established. Based on the statistical analysis of large sample local vibration results and the nonlinear least squares technique, the standard form of the new response spectrum is generated. The analysis shows that the proposed new response spectrum is larger than the standard one at a low damping ratio, and it is safe when compared with the traditional calculation based on the building seismic design code. The new response spectrum presented in this paper has a clear concept and simple form, which can provide a basis for the seismic design of wind power structures.