To synchronize the material transfer and adsorption process of the packaging machine, a combined channel of main and secondary wall panels with multiple negative-pressure suction cups is proposed. The flow field model of the negative-pressure channel is established based on computational fluid dynamics technology. Combined with the RNG k-ε turbulence model and enhanced wall treatment, the effects of channel structural parameters and fan flow on the pressure and velocity distribution are discussed. The results show that the airflow is influenced by expanding pipe, deflector, and fan position. The secondary flow at the expanding pipe intensifies the pressure loss, the deflector near the negative- pressure suction cups reduces the turbulence, and the fan located in the channel center improves the average airflow velocity. Based on the analytic hierarchy process, a quantitative model for the comprehensive performance of flow characteristics is established. When the fan velocity is at 13 m/s, the flow performance of the main and the secondary wall panels increases by 53% and 21%, respectively. However, the effect of the fan is higher than that of the structure when the fan velocity increases to 18 m/s.