To investigate the dynamic response and load transfer path of the isolated structure subjected to multi-direction coupled dynamic excitation， a 1∶4 scale model shaking table test of a three-story irregular plane RC frame isolated structure was conducted.The progressive collapse resistance under multi-direction coupled dynamic excitation was revealed by studying the acceleration response， displacement response， internal force response of the isolation bearing， and concrete and reinforcement strains of the damaged span beam of the structure.Then， the distribution laws of the internal force of the damaged span beam and the damage index of the isolated bearing were analyzed by OpenSees.The results show that under the coupled excitation of the vertical unbalanced load caused by sudden failure of a single isolated bearing and bidirectional horizontal earthquake， the vertical dynamic response at the failure point increases significantly， and the markedvertical deformation occurs.The dynamic effect caused by isolated bearing transient failure has an influence on the internal force of all remaining bearings.In particular，the impact on the neighboring bearing’s internal force is more visible.Vierendeel action and beam end bending moment resist the vertical unbalanced load generated by isolated bearing transient failure.The damage index of neighboring bearings is most affected by the isolated bearing transient failure. The dynamic response of the failure zone under the multi-directional dynamic coupling excitation is more pronounced than that under the vertical unbalanced load only， and the damage index distribution of the isolation layer is more discrete than that under earthquakes only.