For eccentric high-rise buildings with non-coincident centers of mass and rigidity， evaluating the three-dimensional （3D） wind induced effect and the equivalent static wind loads （ESWLs） becomes complicated due to the influence of the 3D mode coupling and aerodynamic coupling of the structure. This paper derives a group of equations based on the mode acceleration method. These equations enable calculating the quasi-static and inertial part of internal force （shear and moment） responses for each floor of eccentric rectangular high-rise buildings， considering the effects of coupling vibration modes and cross-correlations between modal responses. On this basis， evaluation methods for 3D internal force ESWLs along the height distribution are derived. Finally， analyses are conducted to examine the effects of load correlation， structural eccentricity ratio， and aspect ratio on ESWLs combined with three kinds of high-rise building pressure tests. The research results show that for eccentric high-rise buildings， the contribution of mode coupling and load correlation to the structural wind-induced response and ESWLs cannot be ignored. If these two parts are ignored， the three-dimensional equivalent wind load of eccentric high-rise buildings， especially the torsional equivalent wind load， will be underestimated. In addition， different eccentricity ratios and aspect ratios have an impact on the magnitude and distribution of the ESWL for eccentric high-rise buildings. The relevant conclusions can provide guidance for the wind resistance design of eccentric high-rise buildings.