To study the influence law of helices with different parameters on the Vortex-induced Vibration （VIV） characteristics and aerodynamic force of stay cables， the wind tunnel test of a section model was carried out for smooth cables and those with helices. The helix parameters include number， diameter， and winding spacing. The results show that the VIV amplitude of one helix wound on the surface of the stay cable is much larger than that of two or three helices. In the subcritical Reynolds number region， the mean drag coefficient of the stay cable with two helices is smaller than that of the smooth cable， which can be reduced by 10.9% at most. The mean drag coefficient of stay cable with two helices is smaller than that with three helices. When the stay cable is wound with two helices with s=8D， the VIV of the stay cable wound with d<15 mm is obvious. The helix with d≥15 mm can effectively reduce the amplitude of the VIV， and its fluctuating lift coefficient can be reduced obviously compared with the smooth cable， which proves the effectiveness of the winding large-diameter helices in controlling the VIV response. The influence of the winding spacing on the VIV of the stay cable is related to the diameter of the helices. When the diameter is small， the influence of the winding spacing on the VIV is not marked. When the diameter is large， spacing directly affects the suppression effect of VIV.