For biomedical magnesium alloys， Mg-Zn-Ca ternary alloys were prepared by Zn and Ca elements microalloying and high extrusion ratio deformation. The microstructure of the materials was characterized by metallographic analysis and scanning electron microscopy. According to the application scenario， the corrosion resistance of the alloy was evaluated by the combination of conventional electrochemical test and micro-electrochemical test in human simulated body fluid （SBF）. At the same time， the sliding wear property of the material was analyzed by friction and wear test. The results show that the alloy microstructure is the single-phase solid solution by microalloying and hot extrusion. The grain size of the alloy is relatively uniform， the corrosion current density is about 119.33 μA/cm2， and the corrosion mechanism is uniform corrosion. Compared with dry friction， the better corrosion resistance of the material itself co-improves the wear resistance of the material in the simulated body fluid environment. At the same time， the wear rate of the material is significantly reduced with the lubrication effect brought by the simulated body fluid. At this time， the wear mechanism is mainly corrosion wear accompanied by slight abrasive wear.