Because of the lack of an accurate mathematical model of oxide scale removal and process parameters in slurry blasting， the oxide scale of the Q235 hot rolled strip is taken as the research object in this article. According to the energy conservation principle， the kinetic energy change law of the mixed slurry of abrasive particles and water in the slurry blasting process during the impact was analyzed. The strain energy change law of the oxide scale on the surface of the matrix after the slurry blast was analyzed based on the strain energy theory， the mathematical model between the oxide scale removal amount and the slurry blasting process parameters was established， and the finite element ANSYS/ AUTODYN module and smooth particle hydrodynamics are used to simulate the process of oxide scale and matrix deformation during the slurry blasting process. Finally， the integrated descaling test platform is used to carry out the slurry descaling test. The results show that the oxide scale cracks and peels off when the oxide scale strain on the substrate surface is higher than the critical strain， the ratio of the influence of abrasive particle size on the increase rate of impact range to the impact velocity is 105.35%∶24.14%， the ratio of the influence of abrasive particle size on the increase rate of impact depth to the impact velocity is 233.67%∶5.86%， the maximum deviation rate between the finite element calculation and experimental results in the impact range is 8.71%， and the maximum deviation rate of impact depth is 8.55%. The finite element calculation results are consistent with the experimental results， and the model applicability is verified by the results of 304 stainless steel and 45 steel slurry descaling tests.