To study the effect of basalt fiber and cellulose fiber content on compressive， flexural， and splitting tensile strength of hybrid fiber lightweight aggregate high-strength concrete， a response surface regression model was constructed to compare and analyze the measured and predicted mechanical test values， and the optimized concrete mix ratio was obtained by combining the demand function. The results show that the regression model is effective and highly reliable， and the model can be used to analyze the test results. The interaction between the two fibers， the water-cement ratio， and the interaction between cellulose fibers have significant effects on compressive strength， flexural strength， and splitting tensile strength. The model predicts that the optimal water-cement ratio is 0.30， the cellulose fiber content is 0.90 kg/m3， and the basalt fiber content is 4.00 kg/m3. The absolute value of relative errors between the predicted and experimental strength values are all less than 5%， which indicates that the proposed model can provide a reference for multi-objective optimization of the mix ratio of hybrid fiber high-strength concrete.