Abstract:With the advancement of integrated circuit manufacturing technology and the improvement of chip integration，the demand for low-power chips has been steadily increasing. The clock network is responsible for more than 40% of the total power consumption of the chip. Consequently， optimizing the power consumption of the clock network has become one of the most important goals in the design of high-performance integrated circuits. In this paper， a new register clustering method is proposed to generate the leaf level topology of the clock tree. By carefully limiting the fan-out， load， and range of the clusters to reasonably group the registers， the method effectively reduces the number of buffer insertions and the total wiring length， and the clock network power consumption is also significantly reduced. The method is integrated into the traditional clock tree synthesis （CTS） flow， and its effectiveness is tested and analyzed on the ISCAS89 benchmark circuit. Experimental results show that the register clustering method effectively reduces the power dissipation of the clock network by more than 20% and the clock offset by more than 20%， without affecting the maximum delay of the clock tree.

Abstract:MoO3 and KSCN were taken as precursors to synthesize spherical flower-like MoS2 through the hydrothermal method， where MoO3 worked as the source of molybdenum for the reaction， and KSCN provided sulfur， KSCN also worked as the reducing agent of this reaction. With the method of controlling the reaction temperature， changing pH， adding a surfactant， and a large excess of sulfur source in the reagent， many experiments were explored to discover the effects of different experiment parameters on the crystal structure and morphology of MoS2. The optimal conditions of the reaction to obtain the spherical flower-like MoS2 were at 240 ℃， and the pH value is 0.6. Besides， with an excess of KSCN， the size of the MoS2 became smaller and the intervals between the surface sheets also increased. After adding the CTAB， the morphologies of the products became more structured and their sizes became more uniform.

Abstract:In view of the poor sintering resistance of La2Ce2O7 and the low thermal expansion coefficient of La2Zr2O7，the La2Ce2O7 core was first synthesized by hydrothermal method, and then the La2Ce2O7@La2Zr2O7 core-shell nano-powder was successfully synthesized by coprecipitation method. The powder was pre-pressed into pellets and then sintered at 1 100 ℃、1 300 ℃ and 1 500 ℃ for different hours and sintered at 1 100 ~1 500 ℃ for 6 hours, so as to investigate the effect of temperature on its sintering resistance. The morphology and composition of the materials were analyzed by scanning electron microscopy, transmission electron microscopy and energy dispersive spectrometer. The density and micro-hardness of the samples were also tested. Experimental results showed that the La2Ce2O7 core had a cubic or octahedral shape with the average size of about 200 nm. The La2Zr2O7 shell was amorphous structure, and exhibited good enveloping effect on forming a La2Ce2O7@La2Zr2O7 core-shell structure. Constant temperature sintering tests found that the density change rate of the core-shell structure was kept within 2.1%, which was much lower than that of La2Ce2O7 and La2Zr2O7. The distribution of pore and grain size was uniform without cracks and sintering. When sintering temperature was below 1 300 ℃, the La2Ce2O7@La2Zr2O7 was uniformly porous, its density change rate was stable within 10.6%, the grain size was maintained at about 450 nm, and the grain growth rate was close to that of La2Zr2O7，proving its good sintering resistance. When the temperature was higher than 1 300 ℃, however, obvious sintering phenomenon occurred. The densification of La2Ce2O7@La2Zr2O7 accelerated, and its pore size increased and grains grew rapidly, nearly reaching to that of La2Ce2O7. Moreover, the micro-hardness of La2Ce2O7@La2Zr2O7 was slightly higher than that of La2Ce2O7，but much lower than that of La2Zr2O7.

Abstract:N，N，N，N，N′-Pentakis （2-hydroxyethyl）-1，4，7-triazaheptane was synthesized by diethylenetriamine and 2-chloroethanol as the main raw materials. Single-factor experiments and orthogonal experiments were used to optimize the ratio of raw materials and process conditions. The optimum molar ratio of diethylenetriamine and 2-chloroethanol was 1: 6.5，and the optimum process conditions were as follows: reaction temperature was 85 ℃ and reaction time was 5 h. Under the optimal reaction conditions，the yields can reach 98.76 %. The structure of final product was characterized by determining hydroxyl value and amine value，FT-IR，1H-NMR and ES-MS.

Abstract:This paper constructed a model of VRB (all-vanadium redox flow battery),which is suitable for grid simulation.The external characteristics of VRB energy storage system were researched.Then an equivalent model of VRB energy storage system was proposed from the principle of external characteristic equivalent fitting and ignoring the reactive power of the VRB system.This equivalent model has a simple structure, less parameters,and can be identified easily.It can fit the external characteristics of VRB energy storage systems effectively in the case of large disturbance and continuous small disturbance of power system． The advantage is that it can simulate the output limit of the battery energy storage.A GSLM (Generalized Synthesis Load Model) was established in which the proposed VRB equivalent model is connected in parallel with the traditional load model considering distribution network parameters and reactive power compensation, the generalized synthesis load model multiplied with equivalent model is used to fitting the characteristics of power synthesis load containing the VRB energy storage systems.The examples show that, compared with the traditional integrated load model,the GSLM can precisely describe the integrated load characteristics of the distribution network with energy storage system,the greater the proportion of VRB in the synthesis load,the more obvious this advantage,and the parameter identification results of the model have good stability and comprehensive description ability.

Abstract:Ferulic acid and ferulamides are a class of natural products and derivatives with important biological activity and pharmacological effect. Ferulic acid (1) was synthesized from vanillin through Knoevenagel reaction. Then, a series of ferulamides (2-9) were synthesized through reaction of ferulic acid with amines using DCC as dehydrating agent and DMAP as the catalyst. Compounds 7 and 8 are new compounds. The structures of all synthetic compounds were characterized by NMR、MS and IR spectra. This synthetic method has the advantages of easy availability of starting materials, simple operation and high yield.

Abstract:In order to overcome the burst release of water-soluble drugs, reduce dosing frequency and improve curative effect,two new bond-linking type drug-loaded control-releasing systems: Chitosan-Captopril and Chitosan-Lysyl-Captopril were synthesized from captopril as a model drug and chitosan as carriers. The products were characterized by IR, 1H NMR and MS. The accumulation of drug release rates of Chitosan-Captopril are 59.2% in PBS buffer (pH=7.4) and 78.4% in HCl-KCl buffer (pH=1.2). The accumulation of drug release rates of Chitosan-Lysyl-Captopril are 55.2% in PBS buffer (pH=7.4) and 76.4% in HCl-KCl buffer (pH=1.2). The results show that the two kinds of drug-loaded systems eliminate the phenomenon of burst releasing and have excellent sustained release properties, which are expected to become the ideal control-releasing system of water-soluble drugs.

Abstract:3D nitrogen-doped graphene (NRG) was prepared in the hydrothermal method with graphene oxide (GO) as the raw material and melamine as the nitrogenous source and reducing agent. Scanning electron microscopy, X-ray photoelectron spectroscopy, Raman spectroscopy, nitrogen adsorption-desorption analysis and electrochemical measurements were used to characterize the morphology, structure, components and supercapacitor performance of as-prepared electrode materials. The results showed that GO could be reduced efficiently by melamine and realized N-doping at the same time. The 3D structure was built due to the strong interaction between graphene sheets. Its content of nitrogen atoms was 4.37%. The electrochemical performance was measured through electrochemical tests. When the mass ratio of GO and melamine was 1∶2 (NRG-2), the highest specific capacitance of 296 F/g can be achieved at the current density of 1 A/g, which was higher than the capacitance of other mass ratios of GO and melamine. 88.5% of the capacitance of NRG-2 remained after 1000 cycles, which meant that NRG-2 had a long life cycle.

Abstract:A simple and efficient synthesis of β-ketophosphonates was described. The hydrolysis reactions of alkynylphosphonates in the presence of sulphuric acid (3.5 mmol) as a catalyst in the recyclable ionic liquid N·(HSO4)2 afforded the desired β-ketophosphonates in excellent yields（98%）. This method has the advantages of metal-free and tolerance of multifunctional groups. Synthesized compound 2p has not been reported.

Abstract:4-Methylumbelliferone (4-methyl-7-hydroxycoumarin, 1) is a coumarins natural product with important biological activity. Firstly, 4-methylumbelliferone (1) was synthesized from resorcinol and ethyl acetoacetate by Pechmann reaction. Nine coumarin derivatives (2~10) were then synthesized through Mannich reaction, acetylation, Fries rearrangement, O-methylation, Baeyer-Villiger oxidation, O-prenylation and Claisen rearrangement from 4-methylumbelliferone (1). Their inhibitory activities on human cervical carcinoma Hela cells were evaluated in vitro. The biological testing results showed that 4-methyl-5-prenyl-8-hydroxy-7-methoxycoumarin (10, IC50 = 28.58 μmol/L) displayed stronger activity than the positive control drug cis-Platin (IC50 = 41.25 μmol/L), which is worthy of further study.