Taking temperature and humidity independent control air conditioning system as the research project, different models of the system have been established.Through analysis and calculation of each system's COP of a practical engineering project, it reveals the differences in performance and regional differences of the independent control system itself. By comparison,the heat pump wheel dehumidification system should be considered first，where the outdoor air humidity ratio is relatively small. On the other hand,the liquid desiccant dehumidification system and condensate system may be better where the ratio is relatively large.